2-Fluoroanisole CAS No.:321-28-8

2-Fluoroanisole CAS No.:321-28-8

C₇H₇FO

CAS No.:321-28-8

Fill 20 mL vials in the glove box with NFTPT (145 mg, 0.5 mmol, 2 equiv) and (tBuCN)CuOTf (94.7 mg, 0.25 mmol, 1 equiv). Pour 0.25 milliliters of EtOAc into the vial. Seal the vial with a Teflon-lined cap. At 25°C, stir the reaction mixture for 5 minutes. 99.3 mg, 0.25 mmol, and 1 equiv of (2-Methoxyphenyl)tributyltin were added to the reaction mixture. The reaction was allowed to agitate at 25°C for 12 hours. The resulting solution should be diluted with five milliliters of CH2Cl2 or EtOAc. 4-fluoroanisole and 1,3,5-trifluorobenzene (0.025 mmol, 1 equivalent) were added as internal standards. The procedure was analyzed using 19F NMR spectroscopy and GCMS to produce the product 2-fluoroanisole. The synthesis pathway is shown in Figure 1.

An oven-dried screw-capped tube fitted with a stir bar was filled with a mixture of cesium fluoride (90.0 mg, 0.6 mmol, 3.00 equiv), tBuBrettPhos (7.20 mg), aryl triflate (0.20 mmol, 1.00 equiv), tBuOD (19.1 μL, 0.20 mmol, 1.00 equiv, 0.2 mL of toluene solution), cinnamonoyl chloride dimer (2.60 mg, 2.50%), and toluene (1.8 mL). Close the tube. From the glove box, take out the tube. The tube should be placed in an oil bath that has been heated to 120°C. For 12 hours, the reaction mixture was left to stir at 120°C. After cooling, the reaction mixture reached room temperature.Add 40.0 μL (1.55 equiv) of 1-fluoronaphthalene to the mixture. These were then put into screw-cap vials with [(COD)Pd(CH2 SiMe3)2] (3.8 mg, 10 μmol, 5 mol%), tBuBrettPhos (9.7 mg, 20 μmol, 10 mol%), and cesium fluoride (91 mg, 0.6 mmol, 3 eq) in a nitrogen-filled glove box. After that, aryl triflate (0.2 mmol) and toluene (1 mL) were added. Close the vial, take it out of the glove box, and agitate it for 12 to 15 hours at 110°C. The yield was calculated after adding 4-fluorotoluene (0.2 mmol) to the mixture after it had cooled to room temperature. Two-fluoroanisole is the end product. In Figure 2, the synthesis route is displayed.

4.3 mg, 0.012 mmol, 1.2 equiv of 1-chloromethyl-4-fluoro-1,4-diazabicyclo[2.2.2]octanebis (tetrafluoroborate) at 50°C Arylpalladium compound 4a (6.4 mg, 0.010 mmol, 1.0 equiv) was added gradually over a 10-minute period to a solution of acetonitrile-d-3 (0.3 mL). For 20 minutes, the reaction mixture was agitated at 50°C. After cooling the reaction mixture to 23 °C, the 2-fluoroanisole yield was calculated by comparing the resonance integration of 19F NMR (375 MHz, acetonitrile-d-3, 23 °C). Figure 2 depicts the synthesis route.

Packing, Storage, Handling and Transportation

3-Fluorophenol should be kept in dark place under inert atmosphere at room temperature.

Hot Tags: 2-fluoroanisole cas no.:321-28-8, China 2-fluoroanisole cas no.:321-28-8 manufacturers, suppliers, factory, 2 3 4 5 6 Pentafluorophenol PENTAFLUOROPHENOL FOR SYNTHESIS, 99 0 2 3 4 5 6 Pentafluorophenol CAS NO 771 61 9, 99 0 2 4 5 Trifluorobenzyl Bromide CAS NO 157911 56 3,