Fluoromalonic Acid Ester

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Latest Updated Scientific Research Trends of Diethyl Fluoromalonate

 

As a relatively new intermediate, diethyl fluoromalonate has entered the market for less than a decade, and the research data stayed 20 years ago. There are a few papers updated recently. In contrast, with the upgrade of technologies in recent years, diethyl fluoromalonate has drawn more and more attention in the electronics and materials fields. Lifescience will continuously pay attention to the newest dynamics of diethyl fluoromalonate and dimethyl fluoromalonate series intermediates and provide the most updated first-hand documents to our customers and researchers.

What are the Applications of Fluoromalonate
 

In the chemical industry

2-fluoromalonic acid is commonly used as an important raw material for organic synthesis. It can be used To prepare various organic compounds, such as drugs, dyes, polymers, etc. In addition, 2-fluoropropane Diacids can also be used as surfactants, lubricants, plastic additives, and so on.

In the field of biology

2-fluoromalonic acid also has certain application value. It can be used as aIntermediates of certain drugs used for synthesizing biologically active compounds. Meanwhile, 2-fluoropropane Diacids can also be used to study metabolic pathways and biological reactions in organisms.

Types of Fluoromalonate
 
2,4,6-Trifluorobenzoic Acid BUTTPARK 44\01-13
 

Dimethyl Fluoromalonate

Dimethyl fluoromalonate is a chemical compound that belongs to the family of fluorinated organic compounds. It is a clear, colorless liquid with a fruity odor and a boiling point of 115-116 °C. The molecular formula for dimethyl fluoromalonate is C5H7FO4 and its molecular weight is 146.10 g/mol.

 

Diethyl Fluormalonate

Diethyl fluormalonate is a chemical compound with the molecular formula C7H11FO2. It is a colorless liquid that is soluble in water with a strong odor. The compound is often used in the manufacture of various products, including insecticides, pharmaceuticals, and agricultural chemicals.

3,4,5,6-Tetrafluorophthalonitrile CAS NO.1835-65-0
3-Fluorophenol ≥99.0%
 

≥98.0% Dimethyl Fluoromalonate

Dimethyl fluoromalonate, also known as DMFMA, is a versatile and useful compound that has numerous advantages in various fields.

 

Dimethyl Fluoromalonate CAS NO.344-14-9

Dimethyl fluoromalonate is a chemical compound that has revolutionized our lives in a number of ways. This compound has been shown to be useful in a variety of fields, from the pharmaceutical industry to the production of new materials and advanced electronics.

2,3,5,6-Tetrafluoropyridine ≥99.0% 2875-18-5
≥99.0% 2,4,5-Trifluorobenzyl Bromide CAS NO.157911-56-3

 

Safety of Diethyl Fluoromalonate

Diethyl fluoromalonate is identified is a dangerous good (classification VIII) by the Shanghai Research Institute of Chemical Industry Testing Centre, or SRICI. It is slightly corrosive. For now, almost all chemical products, especially liquid, are identified as dangerous goods. This is understandable in the era of increasing safety protection consciousness. According to the analysis of experts in SRICI, the corrosiveness of diethyl fluoromalonate is similar to the edible vinegar in our kitchens. However, as long as it is identified officially as corrosive, diethyl fluoromalonate exporters have to get the necessary documents for export in the original name. If there is any need for the safety materials and export document requirements, please feel free to ask for them via email.

 

Main Specifications of Diethyl Fluoromalonate

Currently, the specifications of diethyl fluoromalonate available in the market cover 80%, 89%, 90%, 93%, 95%, 97%, 98%, and 99%. Adopting the most advanced green chemical engineering production process, Hopewell can manufacture diethyl fluoromalonate with 97% as the lowest purity, our regular product purity is 98%, and the highest purity is >99%. If you have special requirements with the specification, we can produce according to the index you provide.

2,3,4,5,6-Pentafluorophenol CAS NO.771-61-9
Hexafluorobenzene ≥98.5% 392-56-3

Physical and chemical properties of Diethyl Fluoromalonate

 

Product name: Diethyl fluoromalonate
CAS#: 685-88-1
EINECS No.: 211-684-7
Molecular formula: C7H11FO4
Molecular weight: 178.16
Specification: 97%, 98%, 99%
Boiling point: 121-122℃ at 30mmHg (lit.)
Density: 1.129 g/mL at 25 ℃ (lit.)
Package: 200kg/drum
Reflection rate: N20/D 1.407 (lit.)
Flash point: 144 °F
Appearance: Colorless transparent liquid

Synthetic Methods of Diethyl Fluoromalonate

 

There are quite some discussions on the synthetic methods of diethyl fluoromalonate. According to the documents, the mainstream production process of diethyl fluoromalonate includes the carbonyl process, esterification, pyrolysis method, fluoro method, etc. Production processes vary with time. Presently, many reagent companies chloridize diethyl malonate to get diethyl chloromalonate, and then fluoridize diethyl chloromalonate with hydrofluoric acid to get diethyl fluoromalonate. However, using HF or Et3N as a fluoro reagent, there is great safety hidden danger, as well as posing tremendous pressures on the environment. Moreover, the diethyl fluoromalonate produced therefrom cannot be purified further. As a result, the method is not feasible for bulk production. It is only applied in labs for small-quantity synthesis and scientific research.

Hexafluorobenzene C6F6 CAS NO.392-56-3
Storage precautions for fluoromalonate

Store in a cool, ventilated warehouse.

They should be stored separately from oxidants and food chemicals, and avoid mixed storage.

Keep container sealed.

Keep away from fire and heat sources.

The warehouse must be equipped with lightning protection equipment.

The exhaust system should be equipped with a grounding device to conduct static electricity.

Use explosion-proof lighting and ventilation settings.

It is prohibited to use equipment and tools that are prone to sparks.

The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials.

Precautions for Handling Fluoromalonic Acid

 

 

1. Operators should receive special training and strictly abide by operating procedures.
2. Operation and disposal should be carried out in a place with local ventilation or comprehensive ventilation facilities.
3. Avoid contact with eyes and skin, and avoid inhalation of steam.
4. Keep away from fire and heat sources. Smoking is strictly prohibited in the workplace.
5. Use explosion-proof ventilation systems and equipment.
6. If canning is required, the flow rate should be controlled and a grounding device should be installed to prevent the accumulation of static electricity.
7. Avoid contact with incompatible materials such as oxidants.
8. When handling, load and unload with care to prevent damage to packaging and containers.
9. Empty containers may contain harmful substances.
10. Wash your hands after use and prohibit eating and drinking in the workplace.
11. Equip with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment.

Diethyl Fluoromalonate Market Prospect
 

With the Bayer fungicide patent expired globally, more and more agrochemical companies have been initiating new fungicide production projects. This has stimulated the need for diethyl fluoromalonate. In the foreseeable future, agrochemicals will remain the main supply end for diethyl fluoromalonate. With the emergence of new technologies and applications, diethyl fluoromalonate will be applied in more industries. The increasing market demand will expand the production capacity of diethyl fluoromalonate, reducing the price. Lowered prices will push more companies and industries to use diethyl fluoromalonate as raw material. The virtuous cycle presents us with a promising market prospect for diethyl fluoromalonate.

Hexafluorobenzene ≥98.5%
Our Factory
 

Shaoxing Kaibang New Material Technology Co., Ltd is a company integrating R & D, production, sales,professional Pharmaceutical Intermediates manufacturer, we specialize in the development and production of Active Pharmaceutical Intermediates (APIs) and Pharmaceutical Intermediates, and earned a reputations leading supplier of innovative, high quality chemicals. Shaoxing Kaibang New Material Technology Co., Ltd has a well-established research & kilo laboratory to serve our global customers in multi grams to kilograms level, and also conduct process development, has own production line, Pentafluorophenol, Difluorophenol, Tetrafluorobenzyl Alcohol etc as our main competitive products, highly purified,high quality, well appreciated by their purchasers. 

 

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certificate
 
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FAQ

Q: What is diethyl malonate used for?

A: Diethyl malonate, also known as DEM, is the diethyl ester of malonic acid. It occurs naturally in grapes and strawberries as a colourless liquid with an apple-like odour, and is used in perfumes. It is also used to synthesize other compounds such as barbiturates, artificial flavourings, vitamin B1, and vitamin B6.

Q: Is diethyl malonate toxic?

A: Flash point: 85°C c.c. The substance is mildly irritating to the eyes. Evaporation at 20°C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed. The substance is harmful to aquatic organisms.

Q: How is Diethylmalonate prepared?

A: The preparation method of diethyl malonate, include neutralization, cyaniding, acidifying, vacuum hydro-extraction and esterification, washing, steps such as rectification and purification, described neutralization is to use Mono Chloro Acetic Acid and saturated aqueous sodium carbonate reaction to generate sodium ...

Q: What is diethyl malonate also known as?

A: Diethyl malonate, also known as dicarbethoxymethane or ethyl propanedioate, belongs to the class of organic compounds known as dicarboxylic acids and derivatives.The applications of this compound for the synthesis of monocarboxylic acids, dicarboxylic acids, unsaturated acids and ketones have also been discussed.

Q: Is malonic acid bad for you?

A: The substance can be absorbed into the body by inhalation and by ingestion. The substance is severely irritating to the eyes and respiratory tract. The substance is irritating to the skin. Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

Q: What are the hazards of malonate?

A: * Thallous Malonate may cause a skin allergy. If allergy develops, very low future exposure can cause itching and a skin rash. * Thallous Malonate may damage the nervous system causing numbness, "pins and needles," and/or weakness in the hands and feet. * Thallous Malonate may damage the liver and kidneys.

Q: Where is Malonate found?

A: Abstract. Malonate is a three-carbon dicarboxylic acid. It is well known as a competitive inhibitor of succinate dehydrogenase. It occurs naturally in biological systems, such as legumes and developing rat brains, which indicates that it may play an important role in symbiotic nitrogen metabolism and brain development.

Q: How do you make dimethyl malonate?

A: Hydrogen chloride gas is introduced into the mixed liquid of cyanoacetic acid and sodium chloride, and then methanol and sulfuric acid are added for an esterification reaction to obtain dimethyl malonate.

Q: Why is diethyl malonate a weak acid?

A: Dimethyl malonate is soluble (in water) and a very weakly acidic compound (based on its pKa).Thus ethyl acetoacetate and diethyl malonate shows acidity. But the acidity of α-H of carbonyl group is less than acidity of carboxylic acids. Thus their acidity is less.
10.Is malonate and malic acid same?
Malonic acid - American Chemical Society
Malonic acid, formally propanedioic acid, is the second-smallest aliphatic dicarboxylic acid. (Oxalic acid is the smallest.) It should not be confused with malic or maleic acid, both of which also contain two carboxyls. Malonic acid is a white crystalline solid with a decomposition point of ≈135 °C.

Q: What is the role of malonate in this reaction?

A: Malonate is a competitive inhibitor of succinate dehydrogenase, meaning it binds to the enzyme's active site without reacting and so competes with succinate, the enzyme's substrate. As a result, the chemical malonate reduces cellular respiration.Malonate decarboxylase (EC 4.1. 1.88) and citrate lyase (EC 4.1. 3.6) are both large enzyme complexes that consist of multiple subunits, the smallest of which acts as an ACP.

Q: What is the common use of malonic acid?

A: Malonic acid is used as a precursor in polymers and polyester. It is used in flavours as well as in the fragrance industry. It is used to control acidity. It is used in pharmaceutical products.

Q: How will you convert diethyl malonate into glycine?

A: - Step 3: The malonic acid obtained from the reaction with chloroacetic acid is then converted to glycine through a series of N-alkylation, decarboxylation, and acid hydrolysis reactions. These synthesized processes can ultimately yield crotonic acid and glycine from diethyl malonate.

Q: How will you convert diethyl malonate into cinnamic acid?

A: Diethyl malonate dissolved in alcohol (fatty alcohol or aromatic alcohol) and varsol reacts with the potassium hydroxide or the sodium hydroxide to produce potassium malonate monoester or sodium malonate monoester; glacial acetic acid is added to react and produce the malonic ester, the malonic ester and a compound of.

Q: What is dimethyl malonate used for?

A: Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.

Q: How do you make dimethyl malonate?

A: Hydrogen chloride gas is introduced into the mixed liquid of cyanoacetic acid and sodium chloride, and then methanol and sulfuric acid are added for an esterification reaction to obtain dimethyl malonate.

Q: Does diethyl ether have a higher density than water?

A: Diethyl Ether | (C2H5)2O | CID 3283 - PubChem
Diethyl ether appears as a clear colorless liquid with an anesthetic odor. Flash point -49 °F. Less dense than water and slightly soluble in water. Hence floats on water.

Q: What is diethyl malonate also known as?

A: Diethyl malonate, also known as dicarbethoxymethane or ethyl propanedioate, belongs to the class of organic compounds known as dicarboxylic acids and derivatives.Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum.

Q: What does malonate bind to?

A: Malonate inhibits an enzyme involved in cellular respiration. Specifically malonate binds to the active site of the enzyme succinate dehydrogenase (competing with the succinate substrate of the enzyme) inhibiting its function.Malic acid is present in the apple. Malic is derived from the Latin word malum, which means apple. Other fruits like grapes, watermelons, and cherries as well as vegetables like broccoli and carrots, all contain malic acid.

Q: Why is malonate a competitive inhibitor?

A: Malonate is a competitive inhibitor of the compound 'succinate dehydrogenase': malonate attaches to the dynamic site of the enzyme without responding, thus rivals succinate, the typical substrate of the enzyme. Competitive inhibitors are commonly used to make pharmaceuticals.Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionized form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acid's diethyl ester.

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98 0 Dimethyl Fluoromalonate CAS NO 344 14 9, 99 5 3 5 Difluorophenol, 98 Diethyl Fluormalonate CAS NO 685 88 1