Fluorophenol
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What are the Applications of Fluorophenol
Pharmaceuticals
Fluorophenol is one of the key intermediates in the production of several pharmaceuticals like fenticonazole, an antifungal agent that is used to treat skin infections. It is also used in the development of other drugs like Toll-like Receptor 9 (TLR9) agonists.
Agrochemicals
Many agrochemicals like herbicides and insecticides use 3-Fluorophenol as an intermediate. It is also used in the production of abamectin used as a pesticide.
Dyes
Fluorophenol is used as an intermediate in the production of dyes like ethyl violet, which finds applications in the textile industry.Fluorophenol is a vital compound in the chemical industry with widespread use as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes.
Types of Fluorophenol
2,3,4,5,6-Pentafluorophenol
2,3,4,5,6-Pentafluorophenol is a polyfluorinated liquid crystal compound with small spatial site resistance, which is an important intermediate in the preparation of high-performance liquid crystal materials, especially suitable for the preparation of polyfluorinated monomer liquid crystal materials.
3,5-Difluorophenol
3,5-Difluorophenol (DFP) is an important chemical intermediate that has found widespread use in the pharmaceutical, agrochemical, and materials industries. This white crystalline solid has the chemical formula C6H4F2O and a molecular weight of 146.1 g/mol.
3-Fluorophenol
3-Fluorophenol is an organic compound having a chemical formula of C6H5FO. It is an aromatic compound with a fluorine substituent on the ring. This compound is an important industrial chemical, and it is used mainly in the production of other chemicals like pharmaceuticals, agrochemicals, and dyes.
2,3,4,5,6-Pentafluorophenol CAS NO.771-61-9
Pentafluorophenol, also known as 2,3,4,5,6-pentafluorophenol or PFP, is a colorless to pale yellow crystalline solid that belongs to the family of fluorinated benzene derivatives. This compound has a molecular formula of C6HF5O and a molecular weight of 186.06 g/mol.
Structural Properties of Fluorophenol
Fluorophenol can be used as an aromatic compound and as a derivative of phenol, and its chemical properties are similar to phenol. It can react with acids or bases to form corresponding salts. It can undergo oxidation reaction under the action of oxidant to generate the corresponding phenolphthalein compound.
Fluorophenol Chemical Properties
| Melting point | 16.1 °C (lit.) |
| Boiling point | 171-172 °C/741 mmHg (lit.) |
| Density | 1.256 g/mL at 25 °C (lit.) |
| Refractive index | n20/D 1.511(lit.) |
| Fp | 116 °F |
| Storage temp. | Inert atmosphere,Room Temperature |
| Solubility | 37.7g/l |
| Form | Liquid |
| Pka | 8.73(at 25℃) |
| Specific Gravity | 1.256 |
| Color | Clear colorless to light yellow-brownish |
| Water Solubility | 80.72g/L(25 ºC) |
| BRN | 1905112 |
| Stability: | Stable. Flammable. Incompatible with strong oxidizing agents. |
| InChIKey | HFHFGHLXUCOHLN-UHFFFAOYSA-N |
| CAS DataBase Reference | 367-12-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 2-fluoro-(367-12-4) |
| EPA Substance Registry System | o-Fluorophenol (367-12-4) |
Synthesis Method of Fluorophenol
In a dry 10 mL reactor, mix 1 equivalent of p-fluorophenylboronic acid (122 mg, 1 mmol), 2 equivalents of 30% H2O2 (227 mg, 2 mmol), and 10 mg of catalyst in 3 mL of water. The resulting reaction mixture was stirred at room temperature for a period of time, and then the reaction progress was monitored by TLC spot plate. After the reaction was completed, the reaction mixture was directly extracted with diethyl ether and water, the organic layer was separated and dried with anhydrous magnesium sulfate, and filtered to remove the dryness. agent, the residue after the filtrate is concentrated can be separated and purified by silica gel column chromatography (5% ethyl acetate dissolved in petroleum ether), and the solvent is removed by rotary evaporation under reduced pressure to obtain the target product molecule 4-fluorophenol.
| Chemical Properties | Clear colourless to yellow liquid |
| Uses | 2-Fluorophenol is a competitive inhibitor in the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA), a catecholamine precursor that is used as a therapeutic agent for patients with ParkinsonтАЩs disease. 2-Fluorophenol is also used as a sole carbon energy source for bacteria. |
| Synthesis Reference(s) | Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8 |
| Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015 | |
| General Description | Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g / cm3. |
| Air & Water Reactions | Highly flammable. |
| Reactivity Profile | 2-Fluorophenol reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid. |
| Health Hazard | ACUTE/CHRONIC HAZARDS: Toxic and irritant. |
| Purification Methods | Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.] |
2-Fluorophenol Market Trend And Analysis
The 2-Fluorophenol Market has grown significantly in recent years, with an upward trend driven by escalating consumer demand and technical developments. The 2-Fluorophenol Market has experienced a spike in product offers, catering to a variety of demands and interests as sectors embrace innovation. Global expansion has also been aided by favourable economic conditions and strategic alliances.
With the projected integration of cutting-edge technologies and changing Market dynamics, the view for the future is still positive. With a focus on continual improvement and client centricity, the 2-Fluorophenol Market is well-positioned to continue growing and establish itself as a major force in the world economy.
In the coming years, the global 2-Fluorophenol Market is set to experience steady growth, driven by a combination of continuous technological advancements, growing environmental awareness, and the rising need for streamlined operations. To seize the evolving market opportunities, industry players are anticipated to concentrate on product innovation, strategic collaborations, and geographical expansion.
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Shaoxing Kaibang New Material Technology Co., Ltd is a company integrating R & D, production, sales,professional Pharmaceutical Intermediates manufacturer, we specialize in the development and production of Active Pharmaceutical Intermediates (APIs) and Pharmaceutical Intermediates, and earned a reputations leading supplier of innovative, high quality chemicals. Shaoxing Kaibang New Material Technology Co., Ltd has a well-established research & kilo laboratory to serve our global customers in multi grams to kilograms level, and also conduct process development, has own production line, Pentafluorophenol, Difluorophenol, Tetrafluorobenzyl Alcohol etc as our main competitive products, highly purified,high quality, well appreciated by their purchasers.
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FAQ
Q: What is the solubility of 4 fluorophenol?
Q: What is the pKa value of P-fluorophenol?
Q: Why is para chloro phenol more acidic than para fluorophenol?
Q: Which is more acidic O fluorophenol or P fluorophenol?
Q: What is 2 Fluorophenol used for?
Q: What is the pKa of 4 Chlorophenol?
Q: Is fluorophenol acidic?
Q: Does pKa affect lipophilicity?
Q: Which of the following is least acidic fluorophenol?
Q: Why is O fluorophenol weakest acid than P and M fluorophenol?
Q: Why is O chlorophenol more acidic?
Q: Which is the most acidic CHF3?
Q: What is the acidity order of fluorophenol?
Q: What is 2 4 Dichlorophenol used for?
Q: Which of the following is least acidic fluorophenol chlorophenol?
Q: What is 2 6 Dichlorophenol used for?
Q: What is 4-Chlorophenol used for?
Q: Which orbital is the most acidic?
Electronegativity is the ability of an atom to attract a bonded pair of electrons. It is directly proportional to the percent s character. Therefore, sp orbitals have the highest electronegativity. So, sp is more acidic because acid character is also defined in terms of accepting electrons.
Q: Why is O chlorophenol more acidic than phenol?
Q: Which is more acidic O nitrophenol or O Methoxyphenol Why?
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99 5 3 5 Difluorophenol, 99 0 Lithium Bis 1 1 2 2 3 3 4 4 4 nonafluoro 1 butanesulfonyl Imide CAS NO 119229 99 1, 2 3 4 5 6 Pentafluorophenol PENTAFLUOROPHENOL FOR SYNTHESIS