2,4-Difluorobenzyl Alcohol ,Benzenemethanol

C₇H₆F₂O CAS NO.56456-47-4

product-708-746

Application

2,4-difluorobenzaldehyde preparation: The Friedel-Crafts reaction can be used to prepare it. The following are the precise steps:
To the methanol solution, add aluminum chloride and m-difluorobenzene. Then, drain and add carbon monoxide until the system pressure reaches 3.5 MPa.

After three hours of reaction at 60°C, hydrochloric acid was injected to stop the reaction.
To create a translucent, pale yellow liquid, filter and evaporate the majority of the solvent under low pressure.
2,4-difluorobenzyl alcohol preparation: Apply the Grignard reagent process or the Wittig reaction to the produced 2,4-difluorobenzaldehyde. The following are the precise steps:
2,4-difluorobenzaldehyde should be dissolved in a suitable solvent, like tetrahydrofuran.

Add Grignard reagent or Wittig reagent to complete the reaction (e.g., a combination of triphenylphosphine and aldehyde).
Purify using column chromatography or distillation once the process is finished to obtain 2,4-difluorobenzyl alcohol.‌

Physical Properties

Boiling point	194.3±25.0 ℃ at 760 mmHg
Density	1.29 g/mL at 25 °C(lit.)
Molecular mass	144.12
Assay	≥99.0%
Flash point	194℉
Refractive index	N20/D 1.487(lit.)
Package	50kgs or according customer requirement
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