2,4,5-Trifluorobenzyl Bromide

2,4,5-Trifluorobenzyl bromide

C₇H₄BrF₃

CAS NO.157911-56-3

2,4,5-Trifluorobenzyl bromide: A Powerful Building Block for Organic Synthesis

2,4,5-trifluorobenzyl bromide preparation
First method:
Fill the reaction bottle with hydrochloric acid, add sodium bromide and paraformaldehyde at low temperatures, and then add 1,2,4-trifluorobenzene dropwise at room temperature. Control the rate of dropleting and finish the reaction in a few hours. Then, raise the temperature to the desired temperature while maintaining the reaction number. Place crushed ice in the dilution bottle, add the reaction solution, bring the temperature down to less than 60°C, and let it settle. Then, treat the organic layer with diluted acid, neutralize it with sodium carbonate solution, and let it settle again. Finally, distill the organic layer to extract bromine. Benzyl substance. The mass fraction is over 99% and the yield is 85%.
Method two:
Add 100 ml of 98% sulfuric acid to a 250 ml four-neck reaction bottle, cool to 20C, add 21.3 g of paraformaldehyde (equivalent to 0.71 mol of monomeric formazone), 44.8 g of sodium bromide (0.766 mol), and finally add 1, 2,4-trifluorobenzene 50.8g (0.385mol), Insulate the reaction at 40C for 10 hours, pour the reaction solution into ice water, separate the organic layer, wash with water until neutral, dry, steam under reduced pressure and then refine to obtain 58.8g of 2,4,5-trifluorobenzyl bromide, content 99.8 %, yield 84.7%.

Packing, Storage, Handling and Transportation

2,4,5-Trifluorobenzyl bromide should be kept under inert atmosphere at room temperature.

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