2,4-Difluorobenzaldehyde ≥98.0%

2,4-Difluorobenzaldehyde ≥98.0%

C₇H₄F₂O

CAS No.: 1550-35-2

A crucial chemical step, 2,4-Difluorobenzylamine is primarily used in the production of the anti-AIDS medication dolutegravir. GlaxoSmithKline created the novel integrase inhibitor dolutegravir, which was authorized for sale in the US in 2013. Market sales have risen significantly in recent years due to its benefits of high efficiency and low toxicity, and the pace is generally positive. Among the various dolutegravir production pathways now understood, 2,4-difluorobenzylamine is an essential step that cannot be omitted.Therefore, creating a low-cost, environmentally friendly, and effective 2,4-difluorobenzylamine production method is quite important. There are two phases involved in its preparation: A catalyst is needed to facilitate the carbonylation reaction between m-difluorobenzene and CO under specific pressures, which produces 2,4-difluorobenzaldehyde or m-difluorobenzene formyl. Chemical process: 2,4-difluorobenzaldehyde is created by hydrolyzing m-difluorobenzene after it has been replaced with chlorocarbene in a strong alkali system of chloroform (Reimer-Tiemann reaction). b). After being introduced to the alcohol solvent in step a), the 2,4-difluorobenzaldehyde conducts a direct reductive amination reaction with ammonia and hydrogen, or it interacts with ammonium formate to produce 2,4-difluorobenzylamine, at specific pressure and with a catalyst present.

Packing, Storage, Handling and Transportation

Nonafluorobutanesulfonyl fluoride should be kept in dark place, sealed in dry and stored in freezer under -20℃

Hot Tags: 2,4-difluorobenzaldehyde ≥98.0%, China 2,4-difluorobenzaldehyde ≥98.0% manufacturers, suppliers, factory, 99 5 Nonafluoro 1 Butanesulfonyl Chloride, 2 4 5 Trifluorobenzyl Alcohol RARECHEMALBD0314, , Fluorobenzohydroxy Acid