1,2,4-Trifluorobenzene CAS No.:367-23-7

1,2,4-Trifluorobenzene is widely used in the pharmaceutical industry. The compound is essential in the production of several essential drugs, including antipsychotics and anti-depressants. Without this chemical, medical treatments for mental health disorders would be severely limited.

1,2,4-Trifluorobenzene CAS No.:367-23-7

C₆H₃F₃

CAS No.:367-23-7

product-718-757

Application

The following procedures are utilized in the 1,2,4-trifluorobenzene preparation process: (1) Fluoroboric acid and 3,4-difluoroaniline react to form a salt, which subsequently reacts with sodium nitrite to form fluoroboric acid diazonium salt; (2) Fluoroboric acid Boric acid diazonium salt undergoes a high temperature and high pressure reaction at a temperature of 80-300°C to produce 1,2,4-trifluorobenzene without the use of solvents. Risky nitration reactions occur throughout the preparation process. Furthermore, adding fluorine to the purge of the upper meta location is challenging. Because 3,4-difluoroaniline preparation has a high refractive index, 1,2,4-trifluoroaniline synthesis is ultimately more expensive.

In this paper, 2,4-dinitrobenzene is used as the starting feed, and boric acid diazonium salt is prepared through dehydration and reduction, and the target compound 1,2,4-triphenyl is prepared by heating device. The synthesis reaction formula is as follows:

图1 1,2,4-三氟苯的合成反应式.png

Physical Properties

Boiling point	88 °C/759 mmHg (lit.)
Density	1.264 g/mL at 25 °C (lit.)
Molecular mass	132.08
Assay	≥99.0%
Flash point	40 °F
Refractive index	n20/D 1.423(lit.)
Package	200kgs or according customer requirement
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