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Hexafluorobenzene is an organic aromatic compound with the molecular formula C 6F 6. It is a derivative of benzene in which all six hydrogen atoms are replaced by fluorine. Solvents commonly used in photochemical reactions in organic chemistry. In addition, they also have the following uses: F-19 NMR reference material for chemical shift calibration. Solvents and reference materials in C-13 NMR. ¹H Solvents in NMR. Solvents used in certain studies using infrared spectroscopy. UV spectroscopy uses solvents.
What are the Applications of Hexafluorobenzene
The pharmaceutical industry
The application of hexafluorobenzene in pharmaceuticals is mainly used to synthesize various intermediates, such as thiazepam and
Pei Di Yin and other drugs, as well as drugs targeting cancer, liver disease, and neurological diseases.
The pesticide industry
The application of hexafluorobenzene in pesticides is mainly used in the production of metronidazole, azoxystrobin, and other insecticides for pest control Agent to prevent crop damage from pests.
Materials industry
Hexafluorobenzene is mainly used in the synthesis of high-performance polyimide resins, special coatings, and adhesives,As a key component of the material.
Laboratory applications of hexafluorobenzene
Hexafluorobenzene has been used as a reporter molecule to investigate tissue oxygenation in vivo. It is exceedingly hydrophobic, but exhibits high gas solubility with ideal liquid gas interactions. Since molecular oxygen is paramagnetic it causes 19F NMR spin lattice relaxation (R1): specifically a linear dependence R1= a + bpO2 has been reported. HFB essentially acts as molecular amplifier, since the solubility of oxygen is greater than in water, but thermodynamics require that the pO2 in the HFB rapidly equilibrates with the surrounding medium. HFB has a single narrow 19F NMR signal and the spin lattice relaxation rate is highly sensitive to changes in pO2, yet minimally responsive to temperature.
Hexafluorobenzene is commonly used as anesthetic and excellent solvent for many organic substances and is also an important intermediate for the synthesis of perfluorinated aromatic compounds, which has a broad application prospect in chemical industry, medicine and liquid crystal materials.
HFB is typically injected directly into a tissue and 19F NMR may be used to measure local oxygenation. It has been extensively applied to examine changes in tumor oxygenation in response to interventions such as breathing hyperoxic gases or as a consequence of vascular disruption.[8] MRI measurements of HFB based on 19F relaxation have been shown to correlate with radiation response of tumors.[9] HFB has been used as a gold standard for investigating other potential prognostic biomarkers of tumor oxygenation such as BOLD (Blood Oxygen Level Dependent), TOLD (Tissue Oxygen Level Dependent) and MOXI (MR oximetry)A 2013 review of applications has been published.
Hexafluorobenzene (C6F6) is an organic compound that can serve as a solvent in chemical reactions Or reagents. The interaction between hexafluorobenzene and ions mainly involves solvation and ion pairingFace.When ions dissolve in hexafluorobenzene, hexafluorobenzene molecules can pass through its polar molecules The interaction between ions surrounds them, forming solvated ions. This solvation process can To stabilize the presence of ions in solution and reduce the interaction between ions, thereby affecting the dissociation The chemical reactivity of the molecule.In addition, hexafluorobenzene can also form ion pairs with ions, that is, one ion and one hexafluoroBenzene molecules bind together. The formation of this ion pair can affect the solvation state of ions and Chemical reactivity.
Properties and Stability: It is very stable to heat and only undergoes minimal decomposition when heated at 500°C for 3 weeks. It is not as stable against radiation as benzene, and it decomposes mainly to produce polymers. Pentafluorophenol and pentafluoroaniline can be obtained by reacting with bases and other nucleophiles. Less toxic than benzene. Most of them are anesthetics, and their toxicity decreases as the degree of fluoridation increases. The main impurity is pentafluorobenzene. It can be treated with fuming sulfuric acid at room temperature for 4 hours to sulfonate the impurities, then washed with water, dried with phosphorus pentoxide, and crystallized step by step to obtain a refined product with a purity of 99.95% ± 0.05% and a melting point of (5.082 ± 0.005) ℃.
Process of Hexafluorobenzene
Acylation method
Acylation method is a commonly used method for synthesizing hexafluorobenzene, which involves introducing acyl reagents onto the benzene ring to form hexafluorobenzene Substituted benzene compounds. The specific steps are as follows:React benzene with acyl reagents (such as ethyl chloroformate, trifluoromethane, etc.) in the presence of strong acid catalysts,Generate hexafluoro substituted benzene compounds.After the reaction is completed, separate and purify to obtain the hexafluorobenzene product.The advantage of this method is that the synthesis process is relatively simple and the yield is high. The disadvantage is that side reactions are prone to occur during the reaction process, leading to The purity of the product is relatively low.
Aromatic ring addition method
Aromatic ring addition method is a method that utilizes the electron density unsaturation of aromatic rings to generate hexafluorobenzene through addition reactions Law. The specific steps are as follows:Conduct addition reactions between aromatic hydrocarbons and fluorine sources (such as tetrafluoroethylene, hexafluoropropylene, etc.) in the presence of catalysts to generate Hexafluoro substituted aromatic hydrocarbons.Subsequently, cyclization is carried out to generate hexafluorobenzene. The advantage of this method is that the synthesis route is relatively novel, the product purity is high, but the disadvantage is that it requires specific equipment and conditions,The operation is relatively complex.
Electrolytic reduction method
Electrolytic reduction method is a method that utilizes the principle of electrolysis to form hexafluorobenzene by introducing fluorine atoms into the benzene ring. have The body steps are as follows:Mix benzene with appropriate reducing agents (such as sodium, zinc, etc.) and electrolyte for an electrolytic reaction.During the electrolysis process, a reduction reaction occurs on the benzene ring, introducing fluorine atoms to form hexafluorobenzene.The advantages of this method are that the synthesis process is environmentally friendly, safe, and has a high yield. However, the disadvantage is that specific equipment and process conditions are required,And the cost is relatively high.
Hexafluorobenzene Storage Precautions
Store in a cool, ventilated warehouse. Keep away from fire and heat sources. The storage temperature should not exceed 30℃. They should be stored separately from oxidants and food chemicals, and avoid mixed storage. Use explosion-proof lighting and ventilation facilities. It is prohibited to use mechanical equipment and tools that are prone to sparks. The storage area should be equipped with emergency release equipment and suitable containment materials. The "five pairs" management system for extremely toxic substances should be strictly implemented.
Precautions for Handling Hexafluorobenzene
Closed operation, fully ventilated. Operators must undergo special training and strictly abide by operating procedures. It is recommended that the operator wear a self-priming filter gas mask (full face mask), a one-piece tape gas protective suit, and rubber oil-resistant gloves. Keep away from fire and heat sources. Smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent vapors from leaking into the workplace air. Avoid contact with oxidants. When handling, load and unload with care to prevent damage to packaging and containers. Equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Empty containers may be harmful residues.
The future trend of hexafluorobenzene
Improve product quality
With the continuous increase in market demand, hexafluorobenzene enterprises need to improve product quality and strengthen Product research and development, developing high-performance hexafluorobenzene products that meet the needs of different fields.
Expand application areas
Hexafluorobenzene has excellent physical and chemical properties in new materials, biotechnology, coatings, and Many fields such as medicine have broad application prospects, and in the future, hexafluorobenzene enterprises need to expand in multiple fields.
Strengthening environmental protection
Hexafluorobenzene, as an organic fluorine compound, has non degradability and high toxicity Enterprises with hexafluorobenzene need to strictly control pollutant emissions, reduce potential impacts such as environmental pollution and health risks.
The Growth of Market Size Is Mainly Due to the Following Factors
The development of the pharmaceutical industry
Hexafluorobenzene can be used as a raw material and intermediate in the synthesis of various pharmaceuticals and biopharmaceuticals The continuous expansion of this field has promoted the growth of the hexafluorobenzene market size.
The demand of the pesticide industry
Hexafluorobenzene, as one of the important fluorinated aliphatic aromatic hydrocarbons in pesticides, is effective in preventing diseases and pests Harmful aspects play an important role, and the demand for agricultural personnel has also contributed to the increase in the market size of hexafluorobenzene.
The demand for materials industry
Hexafluorobenzene can be used as an intermediate in coatings, plastics, polymers, and rubber, and is environmentally friendly The excellent performance in wear resistance and corrosion resistance has also led to the continuous increase in the market size of hexafluorobenzene.
Our Factory
Shaoxing Kaibang New Material Technology Co., Ltd is a company integrating R & D, production, sales,professional Pharmaceutical Intermediates manufacturer, we specialize in the development and production of Active Pharmaceutical Intermediates (APIs) and Pharmaceutical Intermediates, and earned a reputations leading supplier of innovative, high quality chemicals. Shaoxing Kaibang New Material Technology Co., Ltd has a well-established research & kilo laboratory to serve our global customers in multi grams to kilograms level, and also conduct process development, has own production line, Pentafluorophenol, Difluorophenol, Tetrafluorobenzyl Alcohol etc as our main competitive products, highly purified,high quality, well appreciated by their purchasers.
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FAQ
Q: Is hexafluorobenzene toxic?
Q: Is hexafluorobenzene soluble in water?
Q: What is the solubility of hexafluorobenzene?
Q: How is hexachlorobenzene made from benzene?
Q: Is benzene in all shampoos?
Q: Is hexachlorobenzene banned in the US?
Q: How does hexachlorobenzene affect humans?
Q: What is another name for hexachlorobenzene?
Hexachlorobenzene, or perchlorobenzene, is a chlorobenzene compound with the molecular formula C6Cl6. It is a fungicide formerly used as a seed treatment, especially on wheat to control the fungal disease bunt. It has been banned globally under the Stockholm Convention on Persistent Organic Pollutants.
Q: What removes benzene from the body?
Q: Is benzene in all deodorant?
Q: What does benzene smell like?
Q: Do eggs have benzene?
Q: Does Hairspray have benzene in it?
Q: Which dry shampoo to avoid?
Q: Is hexachlorobenzene still used?
Q: Why was hexachlorobenzene banned?
Q: What diseases does benzene cause?
Q: How is hexachlorobenzene manufactured?
Q: Is hexachlorobenzene a toxic chemical?
Q: What are the symptoms if benzene is absorbed through the skin?
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