1, 3-Difluorobenzene
C6H4F2
CAS No.:372-18-9
Application
1, 3-Difluorobenzene is a colorless liquid with a mild aromatic odor. It is a fluorinated derivative of benzene and is commonly used as a building block in organic synthesis. Its molecular formula is C6H4F2, and its molecular weight is 114.09 g/mol.
One of the most significant applications of 1, 3-difluorobenzene is in the synthesis of pharmaceuticals. It is a versatile intermediate that can be used to prepare a wide range of drugs, including antiviral, antimicrobial, and anti-inflammatory agents. For example, 1, 3-difluorobenzene is used as a starting material for the preparation of raltegravir, a drug used to treat HIV infections.
Besides pharmaceutical applications, 1, 3-difluorobenzene is also used in the production of agrochemicals, dyes, and polymers. In the agricultural sector, it is used as a key intermediate in the manufacture of herbicides and insecticides. In the polymer industry, 1, 3-difluorobenzene is used in the synthesis of high-performance materials such as liquid-crystal polymers.
One of the reasons why 1, 3-difluorobenzene is so popular in organic synthesis is because of its unique chemical properties. The two fluorine atoms on the molecule make it highly electronegative, which means that it can participate in a wide range of reactions. For example, 1, 3-difluorobenzene can undergo nucleophilic substitution, electrophilic aromatic substitution, and Friedel-Crafts reactions, to name a few.
In conclusion, 1, 3-difluorobenzene is an important building block in the field of organic synthesis. Its unique chemical properties make it a versatile intermediate that can be used to prepare a variety of compounds, including pharmaceuticals, agrochemicals, and polymers.
Synonyms:
1,3-difluroethylene;Benzene, m-difluoro-;benzene,1,3-difluoro-;Benzene,m-difluoro-;Between two fluorine benzene;1,3-DifL;Difluoro-1,3-benzene;m-difluoro-benzen
Physical Properties
|
Boiling point |
83 °C |
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Density |
1.163 g/mL at 25 °C(lit.) |
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Molecular mass |
114.09 |
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Assay |
≥99.0% |
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Flash point |
36 °F |
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Refractive index |
n20/D 1.438(lit.) |
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Water solubility |
1.1 g/L |
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Package |
200kgs or according customer requirement |
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Packing, Storage, Handling and Transportation
Hexafluorobenzene should be sealed in dry place at room temperature.
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