Properties and application transformation of 2-fluorophenol
2-Fluorophenol is a colorless and transparent liquid at room temperature and pressure. 2-Fluorophenol is a phenol derivative with significant acidity and pungent odor; due to the electron-withdrawing effect of fluorine atoms on the benzene ring, its acidity is stronger than phenol. 2-Fluorophenol can be used as an intermediate in organic synthesis and pharmaceutical chemistry, and can be used in the preparation and production of disinfectants, fungicides, herbicides, phenolic resins, bisphenol A and caprolactam.
Solubility
2-Fluorophenol can be dissolved in common organic solvents such as dichloromethane, tetrahydrofuran, etc., and can also be dissolved in alkaline aqueous solutions.
Application transformation
Application transformation of 2-fluorophenol
At 0 degrees, a dichloromethane solution of 2-fluorophenol was slowly added dropwise to a fuming nitric acid solution (2.3 equivalents), and then the reaction mixture was stirred at room temperature for 18 hours. After the reaction was completed, the reaction mixture was carefully diluted in water, and then the reaction mixture was extracted three times with dichloromethane. All organic layers were combined and dried over anhydrous sodium sulfate, the desiccant was filtered out and the filtrate was evaporated. Finally, the residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate as eluent to obtain the target product. [1]
Application transformation of 2-fluorophenol
Under argon atmosphere, dimethylthioborane (1 ml, 10.5 mmol, 1 equivalent) was added to a dry reaction flask, the reaction mixture was cooled to zero degrees and then 2-fluorophenol (3.1 ml, 34.7 mmol, 3.3 equivalents) was slowly added to the mixture. The reaction mixture was slowly warmed to room temperature and stirred at room temperature for 12 hours. After the reaction is completed, dimethyl sulfide is removed through a short-path distillation head, and the product is then heated to 100 degrees to remove excess 2-fluorophenol and placed in a vacuum (0.1 mBar) for drying to obtain the target product. [2]
Storage conditions
2-Fluorophenol is chemically stable and will not decompose under normal circumstances. It has significant acidity and is easily neutralized by alkaline substances and is easily destroyed by oxidants and deteriorated. 2-Fluorophenol is a flammable chemical and should be stored in a sealed area away from oxidants and alkaline substances.