3,5-Difluoroanisole

C₇H₆F₂O

CAS No.:93343-10-3

Other English Name

3-difluoroanisile;3,5-DIFLUOROANISOLE;3,5-difluoroanisile;3,5-two fluorineether;3,5-Difluoroanisole98%;3,5-Difluoroanisole>3,5-Difluoroanisole 98%;3,5-Difluoroanisole,97%;3,5- difluorobenzyl ether;1,3-difluoro-5-Methoxybenzene.

35-Difluoroanisole CAS No93343-10-3

Application

5.36 mol (289.44g) of room-temperature sodium methoxide should be added to a 5L three-necked flask that has a thermometer, a spherical condenser tube, and a mechanical stirrer. Based on methanol, the sodium methoxide solution has a 30% concentration. Next, add 1000 milliliters of solvent. Toluene should be added gradually and evenly while stirring at a slow speed in the three-necked flask.
5.36 mol (708 g) of 1,3,5-trifluorobenzene was added dropwise to the reaction bottle while stirring, and the temperature was increased to ensure the reaction took place between 60 and 80°C. Heating was halted and the reaction product was let to cool naturally after the reaction had been running for ten hours.
After cooling, the reaction product undergoes post-processing, which entails:

1) Suction filter the reaction product to produce a solid and a filtrate. Wash the solid twice with methanol. Use 0.1 mol/L hydrochloric acid to get the filtrate's pH down to neutral. Then, let it stand for liquid separation to extract the organic and aqueous phases. Phase: To obtain 3,5-difluoroanisole, take the organic phase and distill it. At 140–148°C, the fractions are recovered after atmospheric distillation;
2) Using methylene chloride, remove the aqueous phase from step 1 and separate the liquids to obtain the aqueous phase and the organic phase. Repeat the process four times, then combine the organic phases and separate the organic phases. 3,5-difluoroanisole is obtained by distillation. At 140–150°C, the fractions are obtained via air distillation.
3) Weigh the 3,5-difluoroanisole after combining it with the ones from steps 1 and 2. 733.28 is the product weight.
95.0% of the 3,5-difluoroanisole product is produced. It has a 99.6% purity after gas chromatography analysis. The acquired product's mass spectrum, which is displayed in Figure 1, verifies that it is 3,5-Difluoroanisole, the intended product.

Chemical safety

product-204-124

Physical Properties

Refractive index	n20/D 1.466(lit.)
Boiling point	145-148°C
Density	1.234 g/mL at 25 °C (lit.)
Molecular mass	144.12
Assay	≥99.0%
Flash point	111 °F
Package	50kgs or according customer requirement
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