Introduction To Quinolones

Quinolones (4-quinolones), also known as pyridino acids or pyridino acids, are a class of synthetic antibacterial drugs. Quinolones are antibacterial drugs that mainly act on Gram-negative bacteria and have a weak effect on Gram-positive bacteria (some varieties have better antibacterial effects on Staphylococcus aureus).
Quinolones have a different point of action than other antibacterial drugs. They target the bacterial deoxyribonucleic acid (DNA). The double-stranded DNA of bacteria is twisted into loops or spirals (called supercoils). The enzyme that causes DNA to form supercoils is called DNA gyrase. Quinolones hinder this enzyme, further causing irreversible damage to the chromosomes and causing bacterial cells to No more division. They show selective toxicity to bacteria. Currently, resistance to many antibiotics in some bacteria can be widely spread through plasmid transmission. This class of drugs is not affected by plasmid-transmitted resistance. Therefore, there is no cross-resistance between this class of drugs and many antibacterial drugs.